Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257625 | 0.84 | ALDH1A1 (0.55) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7256796 | 0.83 | EGFR (0.71) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7257567 | 0.83 | EGFR (0.52) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7261257 | 0.83 | EGFR (0.47) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL2070866 | 0.82 | EGFR (0.57) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7256786 | 0.81 | EGFR (0.46) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7256693 | 0.81 | EGFR (0.50) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7260740 | 0.78 | EGFR (0.47) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7261303 | 0.77 | EGFR (0.47) | EGFRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7262238 | 0.77 | EGFR (0.44) | EGFRALDH1A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645983-B1 | Heterocyclic imines such as 3-(4-methoxyphenyl)-1,4-dihydro-4 -quinolinone, used as anticarcinogenic agents having cytolysis efficiency; side effect reduction | LABORATOIRE L. LAFON (FR) | 2003-11-11 | — | — | US | disclosed |
| EP-1202971-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2002022074-A2 | USE OF 2- AND 4- QUINOLONES FOR INHIBITING INTIMAL NEO-PROLIFERATION | LABORATOIRE L. LAFON (FR) | 2002-03-21 | — | — | WO | disclosed |
| WO-2001012607-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES FOR TREATING CANCERS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |