Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | FASN | P49327 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258000 | 0.92 | F10 (0.48) | LSSCYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7261952 | 0.91 | CYP3A4 (0.43) | LSSCYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7257384 | 0.91 | CYP3A4 (0.54) | LSSCYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7257416 | 0.88 | FASN (0.44) | LSSCYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7257425 | 0.88 | LSS (0.49) | LSSCYP3A4CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL6078696 | 0.86 | F10 (0.48) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL7261674 | 0.86 | CYP3A4 (0.46) | LSSCYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7257485 | 0.86 | HSD11B1 (0.41) | GAA | |
| SCHEMBL6079702 | 0.85 | F10 (0.58) | SMN1; SMN2F10FASNCHRM1 | |
| SCHEMBL7257788 | 0.84 | CYP2C19 (0.51) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | claimed |
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |