SCHEMBL7257673

SCHEMBL7257673

CCOC(=O)c1ccc(NC)s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.55
HDAC4 P56524 1/20 0.55
HDAC1 Q13547 1/20 0.55
HDAC6 Q9UBN7 1/20 0.55
AR P10275 3/20 0.48
NR3C1 P04150 1/20 0.46
HPGD P15428 6/20 0.45
SMN1; SMN2 Q16637 5/20 0.45
ALDH1A1 P00352 5/20 0.45
NPC1 O15118 4/20 0.45
RAB9A P51151 4/20 0.45
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
MAPT P10636 3/20 0.45
KDM4E B2RXH2 2/20 0.45
LMNA P02545 1/20 0.45
CASP3 P42574 1/20 0.45
SENP7 Q9BQF6 1/20 0.45
CDC7 O00311 2/20 0.43
DBF4 Q9UBU7 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10530362 0.85 HDAC3 (0.54) HDAC3HDAC4HDAC1HDAC6AR
SCHEMBL7018973 0.83 HDAC3 (0.73) HDAC3HDAC4HDAC1HDAC6HPGD
SCHEMBL24142017 0.82 NPSR1 (0.55) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL11189181 0.81 HDAC1 (0.47) HDAC3HDAC4HDAC1HDAC6AR
SCHEMBL6356788 0.81 MEN1 (0.56) HDAC3HDAC4HDAC1HDAC6HPGD
SCHEMBL30444002 0.80 AR (0.58) HDAC3HDAC4HDAC1HDAC6AR
SCHEMBL2659566 0.78 HDAC3 (0.62) HDAC3HDAC4HDAC1HDAC6HPGD
SCHEMBL8704326 0.77 HDAC3 (0.50) HDAC3HDAC4HDAC1HDAC6AR
SCHEMBL23745081 0.77 POLB (0.44) HDAC4HDAC1HDAC6HPGDSMN1; SMN2
SCHEMBL5068414 0.77 HDAC3 (0.65) HDAC3HDAC4HDAC1HDAC6HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0728018-B1 New enzymes and prodrugs for ADEPT WELLCOME FOUND (GB) 2003-08-06 EP disclosed
US-6319702-B1 NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER GLAXO WELLCOME, INC. 2001-11-20 US disclosed
US-6140100-A CONJUGATE POLYPEPTIDE WHICH IS TISSUE PREFERENTIAL; ANTICARCINOGENIC AGENTS GLAXO WELLCOME INC. (US) 2000-10-31 US disclosed
EP-0728018-A1 THERAPY THE WELLCOME FOUNDATION LIMITED (GB) 1996-08-28 EP disclosed
WO-1995013095-A2 THERAPY THE WELLCOME FOUNDATION LIMITED (GB) 1995-05-18 WO disclosed