Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257943 | 1.00 | ATM (0.41) | ATMF2NPC1TP53RAB9A | |
| SCHEMBL7254246 | 0.93 | MEN1 (0.41) | ATMF2NPC1TP53RAB9A | |
| SCHEMBL7254244 | 0.93 | MEN1 (0.41) | ATMF2NPC1TP53RAB9A | |
| SCHEMBL5855244 | 0.79 | F2 (0.41) | F2NPC1TP53RAB9APRSS1 | |
| SCHEMBL5855236 | 0.79 | F2 (0.41) | F2NPC1TP53RAB9APRSS1 | |
| SCHEMBL7259971 | 0.76 | CASP1 (0.38) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL5855156 | 0.75 | MEN1 (0.47) | F2PRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL5855365 | 0.73 | MEN1 (0.46) | F2TP53MAPTPRSS1KDM4E | |
| SCHEMBL5855369 | 0.73 | MEN1 (0.46) | F2TP53MAPTPRSS1KDM4E | |
| SCHEMBL7254370 | 0.73 | F2 (0.43) | ATMF2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003011222-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2003-02-13 | — | — | WO | disclosed |