SCHEMBL7258286

SCHEMBL7258286

CSc1nc(C)c(CO)[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.41
HTT P42858 1/20 0.39
MAPT P10636 2/20 0.37
L3MBTL1 Q9Y468 3/20 0.35
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
CSNK2A2 P19784 1/20 0.33
CSNK2B P67870 1/20 0.33
CSNK2A1 P68400 1/20 0.33
NUDT1 P36639 1/20 0.33
ALDH1A1 P00352 4/20 0.33
LMNA P02545 2/20 0.33
PKM P14618 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
HPGD P15428 2/20 0.31
KDM6B O15054 1/20 0.30
KDM4A O75164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5791947 0.80 ALDH1A1 (0.43) MAPTCYP2C9CYP2C19ALDH1A1LMNA
SCHEMBL9281048 0.79 HTT (0.43) KDM4EHTTMAPTL3MBTL1CSNK2A2
SCHEMBL5674014 0.73
Hydrochloric Acid SCHEMBL11466216 0.71 ALDH1A1 (0.39) L3MBTL1ALDH1A1
SCHEMBL10514714 0.71 KDM4E (0.36) KDM4EMEN1KMT2A
SCHEMBL9377414 0.71 HTT (0.47) KDM4EHTTMAPTL3MBTL1CSNK2A2
SCHEMBL8548441 0.70
SCHEMBL5790867 0.70
SCHEMBL5108684 0.67 KDM4E (0.58) KDM4EHTTL3MBTL1CYP2C9CYP2C19
SCHEMBL18094959 0.67 CSF1R (0.44) KDM4EMAPTALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003000690-A1 SYNTHESIS OF HETEROCYCLIC COMPOUNDS EMPLOYING MICROWAVE TECHNOLOGY AVENTIS PHARMACEUTICALS INC. (US) 2003-01-03 WO disclosed