Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456746 | 1.00 | KMT2A (0.36) | KMT2AMEN1LMNASMN1; SMN2DYRK1A | |
| SCHEMBL5462821 | 1.00 | KMT2A (0.36) | KMT2AMEN1LMNASMN1; SMN2DYRK1A | |
| SCHEMBL5467657 | 0.92 | NPSR1 (0.34) | KMT2AMEN1LMNASMN1; SMN2DYRK1A | |
| SCHEMBL7258471 | 0.92 | NPSR1 (0.34) | KMT2AMEN1LMNASMN1; SMN2DYRK1A | |
| SCHEMBL3901120 | 0.92 | DRD2 (0.35) | KMT2AMEN1LMNASMN1; SMN2CLK4 | |
| SCHEMBL7263967 | 0.92 | DRD2 (0.35) | KMT2AMEN1LMNASMN1; SMN2CLK4 | |
| SCHEMBL5459095 | 0.92 | SMN1; SMN2 (0.34) | KMT2AMEN1LMNASMN1; SMN2HTT | |
| SCHEMBL5465956 | 0.92 | MEN1 (0.40) | KMT2AMEN1LMNASMN1; SMN2DYRK1A | |
| SCHEMBL5461828 | 0.92 | MEN1 (0.40) | KMT2AMEN1LMNASMN1; SMN2DYRK1A | |
| SCHEMBL5465616 | 0.92 | SMN1; SMN2 (0.34) | KMT2AMEN1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216250-B1 | THIENOISOXAZOLYL AND THIENYLPYRRAZOLYL PHENOXY SUBSTITUTED PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMA INC (US) | 2003-11-19 | — | — | EP | claimed |