Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514059 | 1.00 | GRIN2B (0.37) | GRIN2BGRIN2CCTSKCD274JAK3 | |
| SCHEMBL7264298 | 1.00 | GRIN2B (0.37) | GRIN2BGRIN2CCTSKCD274JAK3 | |
| SCHEMBL5135426 | 0.87 | GRIN2B (0.38) | GRIN2BGRIN2CCTSKJAK3USP2 | |
| SCHEMBL1949227 | 0.87 | GRIN2B (0.35) | GRIN2BGRIN2CCTSKJAK3USP2 | |
| SCHEMBL14282561 | 0.87 | GRIN2B (0.35) | GRIN2BGRIN2CCTSKJAK3USP2 | |
| SCHEMBL14282367 | 0.84 | GRIN2B (0.33) | GRIN2BGRIN2CCTSKJAK3 | |
| SCHEMBL4569940 | 0.84 | GRIN2B (0.38) | GRIN2BGRIN2CCTSKJAK3USP2 | |
| SCHEMBL19614453 | 0.83 | GRIN2B (0.39) | GRIN2BGRIN2CCTSKJAK3USP2 | |
| SCHEMBL15924562 | 0.83 | GRIN2B (0.39) | GRIN2BGRIN2CCTSKJAK3USP2 | |
| SCHEMBL19614479 | 0.83 | GRIN2B (0.39) | GRIN2BGRIN2CCTSKJAK3USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029736-A1 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-20100029736-A1 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-20080076824-A1 | modified glycinamides: Valine-alphahydroxy-glycinamide | CHRONTECH PHARMA AB (SE) | 2008-03-27 | — | — | US | disclosed |
| US-20080076824-A1 | modified glycinamides: Valine-alphahydroxy-glycinamide | CHRONTECH PHARMA AB (SE) | 2008-03-27 | — | — | US | disclosed |
| WO-2008008551-A2 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| EP-1332134-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002060868-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076824-A1 | modified glycinamides: Valine-alphahydroxy-glycinamide | GALE, ENGASE, UGGT1 | GRIN2B 1961/4885GRIN2C 1945/4885CTSK 2645/4885 |
| US-20100029736-A1 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPSR1 | GRIN2B 71/4885GRIN2C 51/4885CTSK 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.