Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM6A | O15550 | 1/20 | 0.42 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM4B | O94953 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.42 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065155 | 0.93 | KDM4E (0.55) | KDM4EL3MBTL1PSMD14MAP2K1EGLN1 | |
| SCHEMBL7258267 | 0.87 | KDM4E (0.53) | KDM4EL3MBTL1EGLN1ALDH1A1KDM6B | |
| SCHEMBL3241312 | 0.86 | KDM4E (0.54) | KDM4EL3MBTL1PSMD14MAP2K1EGLN1 | |
| SCHEMBL7258018 | 0.85 | KDM4E (0.48) | KDM4EL3MBTL1PSMD14MAP2K1EGLN1 | |
| SCHEMBL4062569 | 0.84 | KDM4E (0.52) | KDM4EL3MBTL1PSMD14MAP2K1EGLN1 | |
| SCHEMBL13993803 | 0.84 | KDM4E (0.52) | KDM4EL3MBTL1PSMD14MAP2K1EGLN1 | |
| SCHEMBL966397 | 0.83 | KDM4E (0.51) | KDM4EL3MBTL1PSMD14MAP2K1EGLN1 | |
| SCHEMBL3239918 | 0.83 | KDM4E (0.51) | KDM4EL3MBTL1PSMD14MAP2K1ALDH1A1 | |
| SCHEMBL14287855 | 0.80 | CALCA (0.45) | KDM4EL3MBTL1EGLN1FTO | |
| SCHEMBL7258791 | 0.78 | KDM4E (0.45) | KDM4EL3MBTL1EGLN1ALDH1A1KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323460-B2 | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-01-29 | — | — | US | disclosed |
| WO-2003077857-A2 | N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |