Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCA | P06881 | 7/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM6A | O15550 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769028 | 0.97 | CALCA (0.74) | CALCAKDM4EKDM4AEGLN1L3MBTL1 | |
| SCHEMBL7258799 | 0.89 | CALCA (0.56) | CALCAKDM4EKDM4AEGLN1L3MBTL1 | |
| SCHEMBL4067727 | 0.87 | CALCA (0.65) | CALCAKDM4EL3MBTL1COMT | |
| SCHEMBL4769035 | 0.85 | CALCA (0.60) | CALCAKDM4EKDM4AEGLN1L3MBTL1 | |
| SCHEMBL4764998 | 0.84 | CALCA (0.54) | CALCAKDM4EKDM4AEGLN1L3MBTL1 | |
| SCHEMBL968119 | 0.84 | CALCA (0.78) | CALCACOMT | |
| SCHEMBL4067964 | 0.84 | CALCA (0.69) | CALCAKDM4EL3MBTL1COMT | |
| SCHEMBL4072599 | 0.83 | CALCA (0.68) | CALCAKDM4EL3MBTL1COMT | |
| SCHEMBL4765018 | 0.82 | CALCA (0.52) | CALCAKDM4EKDM4AEGLN1L3MBTL1 | |
| SCHEMBL4060940 | 0.81 | CALCA (0.95) | CALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003077857-A2 | N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |