Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 14/20 | 0.59 |
| ▸ | ITGA4 | P13612 | 14/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259097 | 1.00 | ITGB1 (0.59) | ITGB1ITGA4POLBACACBMEN1 | |
| SCHEMBL7104368 | 0.90 | ITGB1 (0.69) | ITGB1ITGA4 | |
| SCHEMBL7104374 | 0.90 | ITGB1 (0.69) | ITGB1ITGA4 | |
| SCHEMBL7105616 | 0.83 | ITGB1 (0.40) | ITGB1ITGA4ACACBMEN1KMT2A | |
| SCHEMBL7105624 | 0.83 | ITGB1 (0.40) | ITGB1ITGA4ACACBMEN1KMT2A | |
| SCHEMBL7259095 | 0.76 | ITGB1 (0.47) | ITGB1ITGA4ACACB | |
| SCHEMBL3313882 | 0.75 | ITGB1 (0.53) | ITGB1ITGA4POLB | |
| SCHEMBL7100084 | 0.74 | ITGB1 (0.69) | ITGB1ITGA4 | |
| SCHEMBL7100060 | 0.74 | ITGA4 (1.00) | ITGB1ITGA4 | |
| SCHEMBL7100066 | 0.74 | ITGA4 (1.00) | ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518283-B1 | To modify integrin function in such a way as to beneficially modulate cell adhesion | CELLTECH R&D LIMITED (GB) | 2003-02-11 | — | — | US | disclosed |