Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 5/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | CASR | P41180 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105626 | 0.81 | ACACB (0.35) | ACACBFFAR1CASRPPARGPPARD | |
| SCHEMBL7104374 | 0.78 | ITGB1 (0.69) | ITGB1ITGA4 | |
| SCHEMBL7104368 | 0.78 | ITGB1 (0.69) | ITGB1ITGA4 | |
| SCHEMBL7259097 | 0.74 | ITGB1 (0.59) | ITGB1ITGA4ACACBPOLB | |
| SCHEMBL7259094 | 0.74 | ITGB1 (0.59) | ITGB1ITGA4ACACBPOLB | |
| SCHEMBL7259095 | 0.73 | ITGB1 (0.47) | ITGB1ITGA4ACACBFFAR1HDAC1 | |
| SCHEMBL7100084 | 0.64 | ITGB1 (0.69) | ITGB1ITGA4 | |
| SCHEMBL7101246 | 0.63 | ACE (0.53) | ITGB1PPARGPPARDPPARAMAPK1 | |
| SCHEMBL7101248 | 0.63 | ACE (0.53) | ITGB1PPARGPPARDPPARAMAPK1 | |
| SCHEMBL23137177 | 0.60 | PPARG (0.50) | PPARGPPARACYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518283-B1 | To modify integrin function in such a way as to beneficially modulate cell adhesion | CELLTECH R&D LIMITED (GB) | 2003-02-11 | — | — | US | disclosed |