Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 11/20 | 0.54 |
| ▸ | GSK3B | P49841 | 8/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255610 | 0.83 | GSK3A (0.53) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7256481 | 0.81 | DCLK1 (0.51) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL1460319 | 0.81 | GSK3A (0.59) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7255584 | 0.80 | GABRG2 (0.49) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| Hydrazine SCHEMBL7155128 | 0.79 | GSK3A (0.56) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7256577 | 0.76 | GSK3A (0.54) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7261231 | 0.75 | GSK3A (0.50) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| Water SCHEMBL7155130 | 0.74 | GSK3A (0.55) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7260051 | 0.74 | GSK3A (0.46) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL7260215 | 0.74 | GSK3A (0.46) | GSK3AGSK3BCCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |