Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | CLK2 | P49760 | 3/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.57 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 11/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.52 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7256529 | 0.84 | DYRK1A (0.58) | DYRK1ACDK2CLK2CDK5CLK4 | |
| SCHEMBL7257008 | 0.80 | GSK3A (0.52) | MAPK1GSK3BCDK1GSK3AGRM4 | |
| SCHEMBL7255591 | 0.79 | CDK2 (0.66) | DYRK1ACDK2CLK2CDK5CLK4 | |
| SCHEMBL5388772 | 0.75 | DYRK1A (0.59) | DYRK1ACDK2CLK2CDK5CLK4 | |
| SCHEMBL7259210 | 0.74 | DYRK1A (0.50) | DYRK1ACDK2CLK2CDK5CLK4 | |
| SCHEMBL24393941 | 0.72 | GSK3B (0.75) | DYRK1ACDK2CLK2CDK5CLK4 | |
| SCHEMBL24393936 | 0.71 | GSK3B (0.72) | DYRK1ACDK2CLK2CDK5CLK4 | |
| SCHEMBL5399927 | 0.68 | DYRK1A (0.67) | DYRK1ACDK2CLK2CDK5CLK4 | |
| SCHEMBL1376173 | 0.66 | GSK3B (0.57) | DYRK1ACDK2CLK2CLK4MAPK1 | |
| SCHEMBL5399685 | 0.66 | GSK3B (0.81) | DYRK1ACDK2CLK2CDK5CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |