Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.59 |
| ▸ | CLK2 | P49760 | 5/20 | 0.59 |
| ▸ | CDK2 | P24941 | 4/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.59 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 6/20 | 0.54 |
| ▸ | CDK1 | P06493 | 3/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.54 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7256529 | 0.79 | DYRK1A (0.58) | DYRK1ACDK5CLK4CLK2CDK2 | |
| SCHEMBL7256504 | 0.78 | JAK2 (0.51) | DYRK1ACDK5CLK4CLK2CDK2 | |
| SCHEMBL5395498 | 0.77 | GSK3A (0.57) | DYRK1ACLK2GSK3BGSK3APIM1 | |
| Hydrochloric Acid SCHEMBL6789760 | 0.76 | GSK3A (0.56) | DYRK1ACLK2GSK3BGSK3APIM1 | |
| SCHEMBL7259210 | 0.75 | DYRK1A (0.50) | DYRK1ACDK5CLK4CLK2CDK2 | |
| SCHEMBL7259209 | 0.75 | DYRK1A (0.57) | DYRK1ACDK5CLK4CLK2CDK2 | |
| SCHEMBL7255591 | 0.73 | CDK2 (0.66) | DYRK1ACDK5CLK4CLK2CDK2 | |
| SCHEMBL1460319 | 0.73 | GSK3A (0.59) | CDK5CLK4MAPK8LIMK1MAPK1 | |
| SCHEMBL5399927 | 0.73 | DYRK1A (0.67) | DYRK1ACDK5CLK4CLK2CDK2 | |
| SCHEMBL7255597 | 0.72 | DYRK1A (0.48) | DYRK1ACDK5CLK4CLK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297792-B2 | Pyrazolopyridines and pyrazolopyridazines as antidiabetics | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060223800-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES ADN ANTIDIABETICS | GARLAND STEPHEN | 2006-10-05 | — | — | US | disclosed |
| US-7109199-B2 | Pyrazolopyridines and pyrazolopyridazines as antidiabetics | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-19 | — | — | US | disclosed |
| US-20040019052-A1 | Pyrazolopyridines and pyrazolopyridazines as antidabetics | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-01-29 | — | — | US | disclosed |
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
| EP-1319001-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES AS ANTIDIABETICS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024694-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES AS ANTIDIABETICS | SMITHKLINE BEECHAM, P.L.C. (GB) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223800-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES ADN ANTIDIABETICS | ADK, PDXK, GPR119 | DYRK1A 1135/4885CDK5 743/4885CLK4 250/4885 |
| US-20040019052-A1 | Pyrazolopyridines and pyrazolopyridazines as antidabetics | PDXK, GCK, IAPP | DYRK1A 1841/4885CDK5 1886/4885CLK4 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.