Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020526 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL29053391 | 0.81 | CA12 (0.46) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7139756 | 0.80 | ABL1 (0.31) | ABL1 | |
| SCHEMBL9020222 | 0.80 | HAO1 (0.38) | ALDH1A1MEN1KMT2APOLBTDP1 | |
| SCHEMBL7220738 | 0.78 | ABL1 (0.33) | PPARGPPARAABL1 | |
| SCHEMBL7220710 | 0.78 | PRKDC (0.33) | ALDH1A1MEN1KMT2APKMABL1 | |
| SCHEMBL3311275 | 0.78 | PTPN1 (0.47) | KDM4EALDH1A1HPGDNR1H4PKM | |
| SCHEMBL12919164 | 0.77 | CA1 (0.46) | HPGDKMT2APKMTSHRHSD17B10 | |
| SCHEMBL27358205 | 0.76 | AKR1C3 (0.53) | KDM4EKMT2APPARGPOLBNPC1 | |
| SCHEMBL15997742 | 0.76 | TBXAS1 (0.38) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332134-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002060868-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-08-08 | — | — | WO | disclosed |