Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258422 | 0.93 | DGAT1 (0.51) | DGAT1MCHR1NPC1RAB9AMEN1 | |
| SCHEMBL7260492 | 0.92 | MCHR1 (0.50) | DGAT1MCHR1NPC1RAB9AMEN1 | |
| SCHEMBL7258292 | 0.90 | DGAT1 (0.48) | DGAT1MCHR1NPC1RAB9AMEN1 | |
| SCHEMBL7258396 | 0.89 | DGAT1 (0.60) | DGAT1MCHR1NPC1RAB9AMEN1 | |
| SCHEMBL7260631 | 0.89 | MCHR1 (0.54) | DGAT1MCHR1NPC1RAB9ADRD2 | |
| SCHEMBL7255523 | 0.89 | CCR3 (0.50) | DGAT1MCHR1MEN1KMT2A | |
| SCHEMBL7254624 | 0.88 | DGAT1 (0.58) | DGAT1MCHR1NPC1RAB9AMEN1 | |
| SCHEMBL7255512 | 0.87 | DGAT1 (0.57) | DGAT1MCHR1NPC1RAB9AMEN1 | |
| SCHEMBL7258373 | 0.86 | MCHR1 (0.60) | DGAT1MCHR1DRD2SIGMAR1 | |
| SCHEMBL7255884 | 0.86 | MCHR1 (0.59) | DGAT1MCHR1KCNH2DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003087046-A1 | NOVEL AMINOTETRALINE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS | 7TM PHARMA A/S (DK) | 2003-10-23 | — | — | WO | disclosed |