Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 3/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDE6D | O43924 | 1/20 | 0.45 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632515 | 0.85 | LMNA (0.64) | LMNASMN1; SMN2TNFNOD2NOD1 | |
| SCHEMBL1128817 | 0.81 | HTT (0.62) | LMNASMN1; SMN2TNFPOLBGALR3 | |
| SCHEMBL3970391 | 0.81 | LMNA (0.58) | LMNASMN1; SMN2TNFNOD2NOD1 | |
| SCHEMBL1169953 | 0.79 | LMNA (0.70) | LMNASMN1; SMN2TNFNOD2NOD1 | |
| SCHEMBL4288066 | 0.79 | KDM4E (0.65) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL11268441 | 0.78 | POLB (0.65) | LMNASMN1; SMN2POLBRAB9AALDH1A1 | |
| SCHEMBL31498004 | 0.77 | TNF (0.64) | LMNASMN1; SMN2TNFGALR3NR2F2 | |
| SCHEMBL4191641 | 0.77 | TNF (0.64) | LMNASMN1; SMN2TNFGALR3NR2F2 | |
| SCHEMBL23421979 | 0.77 | KDM4E (0.62) | LMNASMN1; SMN2TNFPOLBGALR3 | |
| SCHEMBL1537633 | 0.77 | LMNA (0.57) | LMNASMN1; SMN2POLBGALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003053941-A2 | BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-ALPHA CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-03 | — | — | WO | disclosed |