SCHEMBL7260957

SCHEMBL7260957

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](OP(=O)(O)OP(=O)(O)O)[C@H]1O

nearest known ligand 0.82

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RNASEL Q05823 5/20 0.82
P2RY1 P47900 3/20 0.78
P2RY2 P41231 2/20 0.78
P2RX1 P51575 2/20 0.78
P2RX3 P56373 2/20 0.78
P2RX2 Q9UBL9 2/20 0.78
SRC P12931 1/20 0.78
P2RX4 Q99571 1/20 0.78
ALDH1A1 P00352 1/20 0.78
SMN1; SMN2 Q16637 1/20 0.78
MACROD2 A1Z1Q3 1/20 0.73
SIRT6 Q8N6T7 1/20 0.73
MACROD1 Q9BQ69 1/20 0.73
TRPM2 O94759 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29675135 1.00 RNASEL (0.82) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL27354655 0.99 RNASEL (0.84) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL11413776 0.99 RNASEL (0.84) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL27254833 0.99 RNASEL (0.84) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL11522022 0.99 RNASEL (0.84) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL668585 0.96 RNASEL (0.77) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL29440267 0.96 RNASEL (0.79) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL905456 0.96 RNASEL (0.79) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL1620290 0.95 RNASEL (0.81) RNASELP2RY1P2RY2P2RX1P2RX3
SCHEMBL1620285 0.95 RNASEL (0.81) RNASELP2RY1P2RY2P2RX1P2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118339282-A Use and method of sulfating a substrate with a mutated arylsulftransferase 赛诺菲 2024-07-12 CN claimed
CN-116676357-A Preparation method of N-sulfonated heparin precursor oligosaccharide 江南大学 2023-09-01 CN claimed
CN-113897342-A PAP high-specificity coupling enzyme YND mutant based on molecular docking, method and application 天津科技大学 2022-01-07 CN claimed
US-10975405-B2 Method for do novo biosynthesis of chondroitin sulfate JIANGNAN UNIVERSITY (CN) 2021-04-13 US claimed
US-20180135089-A1 Method for Do Novo Biosynthesis of Chondroitin Sulfate JIANGNAN UNIVERSITY (CN) 2018-05-17 US claimed
US-20030068802-A1 Use of streptococcus pneumoniae acyl carrier protein synthase crystal structure in diagnostics, antimicrobial drug design, and biosensors ELI LILLY AND COMPANY 2003-04-10 US claimed
US-5514569-A REDUCING INHIBITION OF A NUCLEOSIDE 5'-MONOPHOSPHATE ON PHOSPHODIESTERASE I BY INCUBATING THE ENZYME IN THE PRESENCE OF A NUCLEOSIDE 5'-MONOPHOSPHATE DEGRADING ENZYME HYMAN EDWARD D (US) 1996-05-07 US claimed
CN-118339282-A Use and method of sulfating a substrate with a mutated arylsulftransferase 赛诺菲 2024-07-12 CN disclosed
CN-118339282-A Use and method of sulfating a substrate with a mutated arylsulftransferase 赛诺菲 2024-07-12 CN disclosed
CN-117969431-A Detection reagent and detection method for detecting minoxidil-sulfotransferase activity 北京安图生物工程有限公司 2024-05-03 CN disclosed
CN-116676357-A Preparation method of N-sulfonated heparin precursor oligosaccharide 江南大学 2023-09-01 CN disclosed
CN-113897342-A PAP high-specificity coupling enzyme YND mutant based on molecular docking, method and application 天津科技大学 2022-01-07 CN disclosed
CN-113897342-A PAP high-specificity coupling enzyme YND mutant based on molecular docking, method and application 天津科技大学 2022-01-07 CN disclosed
US-4383031-A LIGANDS; IMMUNOASSAY; SIMPLIFICATION; DIAGNOSIS/MEDICAL/ MILES LABORATORIES, INC. (US) 1983-05-10 US disclosed
US-4380580-A COUPLING, LABELS MILES LABORATORIES, INC. (US) 1983-04-19 US disclosed
US-4363759-A PHOTOSENSITIVE MILES LABORATORIES, INC. (US) 1982-12-14 US disclosed
US-4355165-A CHEMILUMIMESCENCE, IMMUNOASSAY MILES LABORATORIES, INC. (US) 1982-10-19 US disclosed
US-4318980-A Heterogenous specific binding assay employing a cycling reactant as label MILES LABORATORIES, INC. (US) 1982-03-09 US disclosed
US-4261893-A INTERMEDIATES IN SYNTHESIS OF CHEMILUMINESCENT-LABELED CONJUGATES USED IN IMMUNOASSAYS MILES LABORATORIES, INC. (US) 1981-04-14 US disclosed
US-4230797-A NUCLEOTIDE MILES LABORATORIES, INC. (US) 1980-10-28 US disclosed