Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261268 | 0.83 | GSK3A (0.54) | JAK2KDM4EALDH1A1HPGDGAA | |
| SCHEMBL26675449 | 0.81 | JAK2 (0.44) | JAK2KDM4EALDH1A1HPGDGAA | |
| SCHEMBL7257406 | 0.81 | GSK3A (0.55) | JAK2KDM4EALDH1A1HPGDGAA | |
| SCHEMBL12467662 | 0.76 | PDPK1 (0.36) | JAK2KDM4EGAAAURKBAURKA | |
| SCHEMBL14813996 | 0.71 | JAK2 (0.36) | JAK2KDM4EGAARAB9AAURKB | |
| SCHEMBL13329926 | 0.70 | AURKB (0.51) | JAK2KDM4EALDH1A1RAB9AMAPK1 | |
| SCHEMBL30675639 | 0.70 | AURKB (0.51) | JAK2KDM4EALDH1A1RAB9AMAPK1 | |
| SCHEMBL1460319 | 0.69 | GSK3A (0.59) | JAK2RAB9AMAPK1NPSR1GSK3A | |
| SCHEMBL5387619 | 0.69 | GSK3B (0.59) | JAK2GSK3AGSK3BAURKBCSNK1A1 | |
| SCHEMBL16475309 | 0.69 | ALDH1A1 (0.56) | JAK2KDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068773-A1 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |