Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 8/20 | 0.72 |
| ▸ | EHMT2 | Q96KQ7 | 11/20 | 0.69 |
| ▸ | KDM1A | O60341 | 4/20 | 0.69 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.69 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.67 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.67 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.67 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.67 |
| ▸ | WHR1 | P49842 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15280229 | 0.87 | NSD2 (0.80) | NSD2EHMT2KDM1ARCOR1NSD3 | |
| SCHEMBL5530627 | 0.83 | LMNA (0.70) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL7261548 | 0.83 | CCR4 (0.62) | NSD2EHMT2EHMT1WHR1 | |
| SCHEMBL15280265 | 0.82 | EHMT2 (0.77) | NSD2EHMT2KDM1ARCOR1NSD3 | |
| SCHEMBL15280407 | 0.81 | EHMT2 (0.94) | NSD2EHMT2KDM1ANSD3EHMT1 | |
| SCHEMBL15280410 | 0.81 | EHMT2 (0.98) | NSD2EHMT2KDM1ANSD3EHMT1 | |
| SCHEMBL15280243 | 0.81 | EHMT2 (0.75) | NSD2EHMT2KDM1ARCOR1NSD3 | |
| SCHEMBL23073435 | 0.81 | EHMT2 (0.86) | NSD2EHMT2KDM1ANSD3EHMT1 | |
| SCHEMBL15280363 | 0.81 | EHMT2 (1.00) | NSD2EHMT2KDM1ANSD3EHMT1 | |
| SCHEMBL15280242 | 0.81 | EHMT2 (0.86) | NSD2EHMT2KDM1ANSD3EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |