Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.65 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.65 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.65 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.65 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.65 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.65 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.65 |
| ▸ | CCKBR | P32239 | 8/20 | 0.64 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.60 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418478 | 1.00 | PSEN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29404290 | 0.92 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16417117 | 0.92 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4413298 | 0.92 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL33527945 | 0.92 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25314617 | 0.92 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4412727 | 0.89 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4552344 | 0.86 | PSEN1 (0.85) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7696546 | 0.85 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4414764 | 0.83 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653303-B1 | Fused nitroheterocycle with amino and amido functionality; inhibiting beta-amyloid peptide release and/or synthesis; Alzheimer's disease | ATHENA NEUROSCIENCES, INC. | 2003-11-25 | — | — | US | disclosed |