Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7266384 | 0.83 | PDE5A (0.46) | PDE5AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7261585 | 0.75 | CYP1A2 (0.50) | PDE5AKDM4EALDH1A1HSD17B10ALOX15 | |
| SCHEMBL5259886 | 0.75 | HPGD (0.40) | PDE5AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7268690 | 0.74 | PDE1B (0.57) | PDE5AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5258158 | 0.74 | GAA (0.40) | PDE5AKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL7266371 | 0.69 | POLB (0.47) | KDM4EALDH1A1 | |
| SCHEMBL7268662 | 0.68 | RAD52 (0.51) | KDM4EALDH1A1 | |
| SCHEMBL7268608 | 0.68 | PDE5A (0.51) | PDE5A | |
| SCHEMBL7266347 | 0.68 | MEN1 (0.53) | PDE5AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7262638 | 0.67 | SMN1; SMN2 (0.45) | KDM4EALDH1A1HPGDALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |