Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258158 | 0.86 | GAA (0.40) | HPGDKDM4EGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7268690 | 0.79 | PDE1B (0.57) | HPGDKDM4EGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7262638 | 0.79 | SMN1; SMN2 (0.45) | HPGDKDM4ESMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL5263213 | 0.79 | DHPS (0.49) | PDE5AEGFRLMNATP53MAPT | |
| SCHEMBL7267812 | 0.78 | PIK3CA (0.47) | HPGDKDM4EGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7262666 | 0.75 | PDE5A (0.38) | HPGDKDM4EGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL15966833 | 0.73 | ALDH1A1 (0.49) | HPGDGAASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL7261585 | 0.73 | CYP1A2 (0.50) | KDM4EGAASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL7797438 | 0.73 | PDE5A (0.50) | HPGDKDM4ESMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL5261050 | 0.70 | WHR1 (0.49) | KDM4EEGFRNPSR1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040101-B1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-04-25 | — | — | EP | disclosed |
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |