Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | HPGD | P15428 | 8/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | MIF | P14174 | 1/20 | 0.66 |
| ▸ | XDH | P47989 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | MAOA | P21397 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31134786 | 0.88 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL29737520 | 0.88 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL72610 | 0.88 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| Koparin SCHEMBL29477154 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| Koparin SCHEMBL5723673 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL232753 | 0.82 | KDM4E (0.74) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL27869009 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL29929481 | 0.81 | XDH (0.76) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL555129 | 0.81 | XDH (0.76) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL16431730 | 0.79 | MAPT (0.76) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129592-B2 | Plant isoflavonoid hydroxylases and methods of use thereof | THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090142471-A1 | PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF | NOBLE RESEARCH INSTITUTE, LLC | 2009-06-04 | — | — | US | disclosed |
| EP-1720986-A2 | PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF | THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005042747-A2 | PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF | THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) | 2005-05-12 | — | — | WO | disclosed |