Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 14/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | BLK | P51451 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | FRK | P42685 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726969 | 0.86 | RET (0.77) | RETRIPK2SRCLCKBLK | |
| SCHEMBL726539 | 0.84 | RET (0.66) | RETRIPK2SRCLCKBLK | |
| SCHEMBL726543 | 0.82 | RET (0.80) | RETRIPK2SRCLCKBLK | |
| SCHEMBL726560 | 0.81 | RET (0.69) | RETRIPK2SRCLCKBLK | |
| SCHEMBL19763994 | 0.80 | RET (1.00) | RETRIPK2SRCLCKBLK | |
| SCHEMBL726637 | 0.80 | RET (0.76) | RETRIPK2SRCLCKBLK | |
| SCHEMBL726987 | 0.79 | RET (0.71) | RETRIPK2SRCLCKBLK | |
| SCHEMBL728046 | 0.78 | RET (0.69) | RETRIPK2SRCLCKBLK | |
| SCHEMBL728202 | 0.78 | RET (0.69) | RETRIPK2SRCLCKBLK | |
| SCHEMBL727933 | 0.77 | RET (0.62) | RETRIPK2SRCEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003544-A1 | PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-12 | — | — | WO | disclosed |