Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.47 |
| ▸ | NMUR2 | Q9GZQ4 | 5/20 | 0.44 |
| ▸ | NMUR1 | Q9HB89 | 5/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL11129510 | 1.00 | EPHA2 (0.47) | EPHA2NMUR2NMUR1OPRM1OPRD1 | |
| Arginine SCHEMBL7270505 | 0.94 | SLC6A2 (0.48) | EPHA2NMUR2NMUR1OPRM1ACE | |
| Arginine SCHEMBL7264388 | 0.94 | OPRM1 (0.46) | EPHA2NMUR2NMUR1OPRM1ACE | |
| Arginine SCHEMBL7270315 | 0.94 | EPHA2 (0.47) | EPHA2NMUR2NMUR1OPRM1ACE | |
| Arginine SCHEMBL7264437 | 0.93 | OPRM1 (0.41) | EPHA2NMUR2NMUR1OPRM1ACE | |
| Arginine SCHEMBL7264226 | 0.93 | OPRM1 (0.41) | EPHA2NMUR2NMUR1OPRM1ACE | |
| SCHEMBL7270558 | 0.92 | ACE (0.47) | EPHA2NMUR2NMUR1OPRM1ACE | |
| Arginine SCHEMBL7270487 | 0.91 | SLC6A2 (0.53) | EPHA2NMUR2NMUR1OPRM1OPRD1 | |
| Arginine SCHEMBL7271460 | 0.91 | EPHA2 (0.43) | EPHA2NMUR2NMUR1OPRM1ACE | |
| Arginine SCHEMBL7264275 | 0.89 | ACE (0.41) | EPHA2NMUR2NMUR1OPRM1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |
| US-4536395-A | DIPEPTIDES | AJINOMOTO CO., INC. (JP) | 1985-08-20 | — | — | US | disclosed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | disclosed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | disclosed |