⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028184 | 1.00 | — | — | |
| SCHEMBL8786738 | 1.00 | — | — | |
| SCHEMBL17293582 | 0.84 | — | — | |
| SCHEMBL17293338 | 0.84 | — | — | |
| SCHEMBL17293469 | 0.84 | — | — | |
| SCHEMBL24425971 | 0.72 | — | — | |
| SCHEMBL13494257 | 0.72 | — | — | |
| SCHEMBL7431017 | 0.72 | — | — | |
| SCHEMBL13370650 | 0.70 | — | — | |
| SCHEMBL4017747 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729456-B1 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDOL-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| EP-0729456-A1 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDOL-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5508411-A | Process for preparing (S)-1-[2(S)-(1,3-dihyrdro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4,-tetrahydro-2-pyridine-carboxylic acid methyl ester | MERRELL PHARMACEUTICALS INC. | 1996-04-16 | — | — | US | disclosed |
| US-5502253-A | Cyclohex-2-enyl acetamides | MERRELL PHARMACEUTICALS INC. | 1996-03-26 | — | — | US | disclosed |
| WO-1995014663-A2 | NOVEL PROCESS FOR PREPARING (S)-1-[2(S)-(1,3-DIHYDRO-1,3-DIOXO-ISOINDO-2-YL)-1-OXO-3-PHENYLPROPYL]-1,2,3,4-TETRAHYDRO-2-PYRIDINE-CARBOXYLIC ACID METHYL ESTER AND INTERMEDIATES THEREOF | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| EP-0322914-B1 | Novel sulfhydryl containing tricyclic lactams and their pharmacological methods of use | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| EP-0249223-B1 | NOVEL ANTIHYPERTENSIVE AGENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095110-A | Process for the preparation of sulfhydryl containing tricyclic lactams | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| US-4973585-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | MERRELL DOW PHARMACEUTICALS (US) | 1990-11-27 | — | — | US | disclosed |
| EP-0322914-A2 | Novel sulfhydryl containing tricyclic lactams and their pharmacological methods of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-07-05 | — | — | EP | disclosed |
| US-4824832-A | INHIBIT ANGIOTENSIN CONVERTING ENZYME | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-04-25 | — | — | US | disclosed |
| CN-87104166-A | Antihypertensive medicine | — | 1988-01-20 | — | — | CN | disclosed |