⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028184 | 0.72 | — | — | |
| SCHEMBL8786738 | 0.72 | — | — | |
| SCHEMBL7265102 | 0.72 | — | — | |
| SCHEMBL8786649 | 0.72 | — | — | |
| SCHEMBL12945064 | 0.72 | — | — | |
| SCHEMBL23894380 | 0.72 | — | — | |
| SCHEMBL31297943 | 0.72 | — | — | |
| SCHEMBL10575890 | 0.72 | — | — | |
| SCHEMBL14428496 | 0.72 | — | — | |
| SCHEMBL29526569 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322914-B1 | Novel sulfhydryl containing tricyclic lactams and their pharmacological methods of use | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| CN-1020612-C | METHOD FOR PREPARING ANTIHYPERTENSIVE TRICYCLIC LACTAM DERIVS. | MERRELL PHARMA INC (US) | 1993-05-12 | — | — | CN | disclosed |
| US-5095110-A | Process for the preparation of sulfhydryl containing tricyclic lactams | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| US-4973585-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | MERRELL DOW PHARMACEUTICALS (US) | 1990-11-27 | — | — | US | disclosed |
| CN-1034721-A | New tricyclic lactam that contains sulfydryl and the method for on pharmacology, using thereof | MERRELL DOW PHARMA (US) | 1989-08-16 | — | — | CN | disclosed |
| US-4824832-A | INHIBIT ANGIOTENSIN CONVERTING ENZYME | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-04-25 | — | — | US | disclosed |