Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 6/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 6/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 6/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MYLK | Q15746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272032 | 0.92 | ALDH1A1 (0.48) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL9475062 | 0.90 | ALDH1A1 (0.49) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL9476068 | 0.89 | CACNA1F (0.54) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL10911256 | 0.89 | CACNA1F (0.56) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL9477182 | 0.89 | CACNA1F (0.51) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL9475055 | 0.89 | MAPT (0.55) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL9476292 | 0.88 | CACNA1F (0.53) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL7271991 | 0.87 | CACNA1F (0.46) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL10358750 | 0.85 | ALDH1A1 (0.46) | ALDH1A1MAPTKMT2AMEN1CACNA1F | |
| SCHEMBL10358763 | 0.83 | ALDH1A1 (0.46) | ALDH1A1MAPTKMT2AMEN1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237347-B1 | 1,2,3,4-Tetrahydro-6-substituted-4-aryl (or heterocyclo)-3-[(substituted amino)carbonyl]-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4855301-A | 1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E. R. SQUIBB & SONS, INC. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0237347-A2 | 1,2,3,4-Tetrahydro-6-substituted-4-aryl (or heterocyclo)-3-[(substituted amino)carbonyl]-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |