Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL1185253 | 1.00 | SIRT1 (0.47) | SIRT1ITGB3ITGA2BTRPV1ALDH1A1 | |
| SCHEMBL1184796 | 0.90 | SIRT1 (0.51) | SIRT1ITGB3ITGA2BTRPV1PYGL | |
| [3-(Hydroxymethyl)Phenyl]Guanidine SCHEMBL5355312 | 0.89 | TRPV1 (0.48) | ITGB3ITGA2BTRPV1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL538619 | 0.88 | SIRT1 (0.50) | SIRT1ITGB3ITGA2BTRPV1PYGL | |
| SCHEMBL18980991 | 0.84 | SIRT1 (0.48) | SIRT1ITGB3ITGA2BTRPV1ALDH1A1 | |
| Nitric Acid SCHEMBL2076135 | 0.82 | TSHR (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2AALOX12 | |
| Nitric Acid SCHEMBL27716568 | 0.81 | MAPT (0.42) | ITGB3ITGA2BTRPV1ALDH1A1SMN1; SMN2 | |
| Nitric Acid SCHEMBL1185784 | 0.81 | MAPT (0.42) | ITGB3ITGA2BTRPV1ALDH1A1SMN1; SMN2 | |
| Nitric Acid SCHEMBL2073972 | 0.79 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2AAOC3 | |
| Nitric Acid SCHEMBL2075832 | 0.78 | KMT2A (0.53) | TRPV1ALDH1A1SMN1; SMN2GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579983-B1 | Potent and selective inhibitors of receptor tyrosine kinases involved in angiogenesis, especially KDR kinase and/or FGFr kinase | CELLTECH R&D LIMITED (GB) | 2003-06-17 | — | — | US | disclosed |
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | FLT1, FGFR1, KDR | SIRT1 1749/4885ITGB3 1315/4885ITGA2B 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.