⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162411 | 0.77 | — | — | |
| SCHEMBL5944718 | 0.69 | — | — | |
| SCHEMBL20162403 | 0.67 | — | — | |
| SCHEMBL28737261 | 0.67 | — | — | |
| SCHEMBL7004941 | 0.62 | — | — | |
| SCHEMBL28785551 | 0.62 | — | — | |
| SCHEMBL9625479 | 0.62 | — | — | |
| SCHEMBL2326 | 0.62 | — | — | |
| SCHEMBL23437060 | 0.61 | — | — | |
| SCHEMBL6653531 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052300-B1 | C-3-LINKED 1,4-DIHYDROPYRIDINES, THEIR USE IN PHARMACEUTICAL PREPARATIONS AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1985-02-13 | — | — | EP | claimed |
| CN-113166114-A | Cyclic tetramer compounds as proprotein convertase subtilisin/KEXIN 9 type (PCSK9) inhibitors for the treatment of metabolic disorders | 诺华股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-0207514-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1993-09-29 | — | — | EP | disclosed |
| US-4824837-A | VASODILATORS | SUNTORY LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0093945-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1988-11-23 | — | — | EP | disclosed |
| EP-0207514-A2 | 1,4-Dihydropyridine derivatives, process for preparing them, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |
| US-4495192-A | HYPOTENSIVE AGENTS; VASODILATORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-22 | — | — | US | disclosed |
| EP-0093945-A2 | 1,4-Dihydropyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-11-16 | — | — | EP | disclosed |