Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267535 | 0.89 | CACNA1F (0.52) | CACNA1FCACNA1DCACNA1SCACNA1CGUSB | |
| SCHEMBL7266744 | 0.88 | CACNA1F (0.48) | CACNA1FCACNA1DCACNA1SCACNA1CGUSB | |
| SCHEMBL7267803 | 0.84 | CACNA1B (0.41) | CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B | |
| SCHEMBL7267485 | 0.82 | CACNA1B (0.53) | CACNA1BHTT | |
| SCHEMBL7275626 | 0.80 | CACNA1F (0.48) | CACNA1FCACNA1DCACNA1SCACNA1CNOTCH1 | |
| SCHEMBL7265490 | 0.80 | CACNA1F (0.57) | CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B | |
| SCHEMBL7273432 | 0.80 | CACNA1C (0.48) | CACNA1FCACNA1DCACNA1SCACNA1CGUSB | |
| SCHEMBL7265905 | 0.79 | CACNA1F (0.50) | CACNA1FCACNA1DCACNA1SCACNA1CGUSB | |
| SCHEMBL7272338 | 0.79 | CACNA1F (0.73) | CACNA1FCACNA1DCACNA1SCACNA1CGUSB | |
| SCHEMBL7273057 | 0.79 | CACNA1F (0.50) | CACNA1FCACNA1DCACNA1SCACNA1CGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920225-A | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1990-04-24 | — | — | US | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |