Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HK1 | P19367 | 3/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344155 | 0.86 | KCNH2 (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL1325249 | 0.84 | AXL (0.55) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7346817 | 0.81 | PDE3B (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL260120 | 0.81 | NPC1 (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10952826 | 0.80 | CYP11B1 (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10802638 | 0.77 | PDE4A (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8477225 | 0.77 | MAPT (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10803917 | 0.76 | DYRK1A (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL3650037 | 0.74 | PDE3B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11081038 | 0.74 | PDE3B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085227-B1 | THIADIAZINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-03 | — | — | EP | claimed |
| EP-0618204-B1 | HETEROCYCLIC COMPOUND AND CARDIOTONIC CONTAINING THE SAME AS ACTIVE INGREDIENT | ZENYAKU KOGYO KK (JP) | 1998-06-10 | — | — | EP | disclosed |
| US-5574033-A | Heterocyclic compound and cardiotonic agent containing the same as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-11-12 | — | — | US | disclosed |
| US-5446042-A | Heterocyclic compound and cardiotonic agent containing the same as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0618204-A1 | HETEROCYCLIC COMPOUND AND CARDIOTONIC CONTAINING THE SAME AS ACTIVE INGREDIENT | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 1994-10-05 | — | — | EP | disclosed |
| EP-0085227-B1 | THIADIAZINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-03 | — | — | EP | disclosed |
| EP-0226641-B1 | OXODIAZINE COMPOUNDS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-10-18 | — | — | EP | disclosed |
| US-4788194-A | CARDIOTONIC AGENTS, HYPOTENSIVE AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-11-29 | — | — | US | disclosed |
| US-4716164-A | CARDIOTONIC, HYPOTENSIVE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-12-29 | — | — | US | disclosed |
| US-4713381-A | ANTICOAGULANTS, ANALGESICS, ANTIINFLAMMATORY AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1987-12-15 | — | — | US | disclosed |
| EP-0226641-A1 | OXODIAZINE COMPOUNDS. | YOSHITOMI PHARMACEUTICAL (JP) | 1987-07-01 | — | — | EP | disclosed |
| WO-1986007059-A2 | OXODIAZINE COMPOUNDS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1986-12-04 | — | — | WO | disclosed |
| US-4558045-A | CARDIOTONIC AND HYPOTENSIVE ACTIVITY | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1985-12-10 | — | — | US | disclosed |
| US-4489073-A | HYPOTENSIVE AND CARDIOTONIC AGENTS | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1984-12-18 | — | — | US | disclosed |
| EP-0085227-A1 | Thiadiazine derivatives, and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-08-10 | — | — | EP | disclosed |