Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265442 | 0.86 | PDE3B (0.45) | KCNH2PDE3BPDE4APDE4BPDE4C | |
| SCHEMBL9780099 | 0.80 | KCNH2 (0.42) | KCNH2PDE3BPDE4APDE4BPDE4C | |
| Senazodan SCHEMBL1652002 | 0.77 | KCNH2 (1.00) | KCNH2PDE3BPDE4APDE4BPDE4C | |
| SCHEMBL10814165 | 0.76 | PDE4A (0.46) | PDE3BPDE4APDE4BPDE4CPDE4D | |
| Senazodan SCHEMBL4519202 | 0.75 | KCNH2 (0.97) | KCNH2PDE3BPDE4APDE4BPDE4C | |
| Senazodan SCHEMBL1649599 | 0.75 | KCNH2 (0.97) | KCNH2PDE3BPDE4APDE4BPDE4C | |
| SCHEMBL260120 | 0.75 | NPC1 (0.56) | PDE3BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7346817 | 0.75 | PDE3B (0.47) | PDE3BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1325249 | 0.75 | AXL (0.55) | PDE3BPDE4APDE4BPDE4CPDE4D | |
| Senazodan SCHEMBL4526209 | 0.74 | KCNH2 (0.94) | KCNH2PDE3BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8012672-A | — | — | None | — | — | JP | disclosed |
| US-5567699-A | CARDIOTONIC AGENT | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-10-22 | — | — | US | disclosed |
| JP-H0812672-A | THIADIAZINONE DERIVATIVE | MITSUBISHI CHEM CORP | 1996-01-16 | — | — | JP | disclosed |
| EP-0679651-A2 | Thiadiazinone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-11-02 | — | — | EP | disclosed |