Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.98 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.98 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.98 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.98 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266089 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7273036 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7340234 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Hydrochloric Acid SCHEMBL10370157 | 0.82 | PDE4A (0.95) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7338933 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265164 | 0.79 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL30831804 | 0.77 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7266072 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265112 | 0.77 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265073 | 0.76 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264729-B1 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4743612-A | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure | BERLEX LABORATORIES, INC. (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0264729-A2 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1988-04-27 | — | — | EP | disclosed |