Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 19/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 19/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 19/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 2/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265713 | 0.99 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7273036 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7340234 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Hydrochloric Acid SCHEMBL10370157 | 0.83 | PDE4A (0.95) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7338933 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265164 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL30831804 | 0.78 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7266072 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265112 | 0.78 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265073 | 0.77 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110471-A | ADMINISTERING PHOSPHODIESTERASE FOR INHIBITION OF THE CYCLES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2000-08-29 | — | — | US | claimed |
| EP-0264729-B1 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1992-03-25 | — | — | EP | claimed |
| EP-0169164-B1 | IMIDAZOLONECARBONYLARYLIMIDAZOLES; METHOD OF MANUFACTURE, METHOD OF USE AND COMPOSITIONS USEFUL THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-31 | — | — | EP | claimed |
| EP-0264729-A2 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1988-04-27 | — | — | EP | claimed |
| US-4556665-A | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones | SCHERING A.G. (DE) | 1985-12-03 | — | — | US | claimed |
| JP-63104964-A | — | — | None | — | — | JP | disclosed |
| EP-0264729-B1 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| EP-0454773-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | Bundgaard, Hans (DK) | 1991-11-06 | — | — | EP | disclosed |
| WO-1990008128-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | BUNDGAARD HANS (DK) | 1990-07-26 | — | — | WO | disclosed |
| US-4937258-A | Pyrrolo[1,2-c]imidazolone derivatives as PDE inhibitors | BERLEX LABORATORIES, INC. (US) | 1990-06-26 | — | — | US | disclosed |
| EP-0169164-B1 | IMIDAZOLONECARBONYLARYLIMIDAZOLES; METHOD OF MANUFACTURE, METHOD OF USE AND COMPOSITIONS USEFUL THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-31 | — | — | EP | disclosed |
| JP-S63104964-A | PRODRUG DERIVATIVE OF CARDIAC STIMULANT 4-ETHYL-1,3-DIHYDRO-5-(4-(2-METHYL-1H-IMIDAZOL- 1-YL)BENZOYL)-2H-IMIDAZOLE-2-ONE | BERURETSUKUSU LAB INC | 1988-05-10 | — | — | JP | disclosed |
| US-4743612-A | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure | BERLEX LABORATORIES, INC. (US) | 1988-05-10 | — | — | US | disclosed |
| US-4743612-A | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure | BERLEX LABORATORIES, INC. (US) | 1988-05-10 | — | — | US | disclosed |
| US-4743612-A | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure | BERLEX LABORATORIES, INC. (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0264729-A2 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1988-04-27 | — | — | EP | disclosed |
| EP-0264729-A2 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1988-04-27 | — | — | EP | disclosed |
| US-4709043-A | Process for the preparation of imidazolonecarbonylarylimidazoles | SCHERING A.G. (DE) | 1987-11-24 | — | — | US | disclosed |
| EP-0169164-A1 | Imidazolonecarbonylarylimidazoles; method of manufacture, method of use and compositions useful thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-01-22 | — | — | EP | disclosed |
| US-4556665-A | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones | SCHERING A.G. (DE) | 1985-12-03 | — | — | US | disclosed |