Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269180 | 0.77 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7267119 | 0.76 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7273172 | 0.75 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265236 | 0.74 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7271896 | 0.73 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265710 | 0.72 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265400 | 0.71 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7265134 | 0.71 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL30831804 | 0.71 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10669696 | 0.70 | KMT2A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264729-B1 | Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)-benzoyl]]-2H-imidazol-one | BERLEX LABORATORIES, INC. (US) | 1992-03-25 | — | — | EP | claimed |