Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7437711 | 0.99 | HTR4 (0.49) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL7266681 | 0.85 | NOTUM (0.53) | HTR4TMEM97SIGMAR1HTR3A | |
| Hydrochloric Acid SCHEMBL7439063 | 0.84 | NOTUM (0.52) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL10361731 | 0.83 | TMEM97 (0.46) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL9601595 | 0.82 | TMEM97 (0.43) | HTR4TMEM97SIGMAR1HTR3A | |
| Hydrochloric Acid SCHEMBL7446598 | 0.82 | TMEM97 (0.45) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL7432965 | 0.75 | HTR4 (0.50) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL7266518 | 0.74 | SMN1; SMN2 (0.67) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL10246760 | 0.73 | NOTUM (0.64) | — | |
| Hydrochloric Acid SCHEMBL7447009 | 0.73 | SMN1; SMN2 (0.65) | HTR4TMEM97SIGMAR1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278173-B1 | Use of heterocyclic derivatives in the treatment of depressions | GLAXO GROUP LTD (GB) | 1993-11-03 | — | — | EP | claimed |
| EP-0247266-B1 | INDOLE DERIVATIVES HAVING AN AZABICYCLIC SIDE CHAIN, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, AND PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1993-03-10 | — | — | EP | claimed |
| EP-0247266-A1 | Indole derivatives having an azabicyclic side chain, process for their preparation, intermediates, and pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1987-12-02 | — | — | EP | claimed |
| EP-0278173-B1 | Use of heterocyclic derivatives in the treatment of depressions | GLAXO GROUP LTD (GB) | 1993-11-03 | — | — | EP | disclosed |