Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.31 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266900 | 1.00 | GRIK1 (0.35) | GRIK1FNTAFNTBTHRBPGGT1B | |
| SCHEMBL15373390 | 0.82 | BLM (0.35) | LMNAALOX15BLMPMP22LDHA | |
| SCHEMBL3133846 | 0.80 | HDAC3 (0.43) | GRIK1FNTAFNTBTHRBPGGT1B | |
| SCHEMBL12490349 | 0.80 | HDAC3 (0.43) | GRIK1FNTAFNTBTHRBPGGT1B | |
| SCHEMBL12200413 | 0.79 | GRIK1 (0.43) | GRIK1FNTAFNTBTHRBPGGT1B | |
| SCHEMBL19813750 | 0.79 | FNTA (0.37) | GRIK1FNTAFNTBTHRBPGGT1B | |
| SCHEMBL19813751 | 0.79 | FNTA (0.37) | GRIK1FNTAFNTBTHRBPGGT1B | |
| Bromide SCHEMBL20239734 | 0.78 | FNTA (0.42) | GRIK1FNTAFNTBTHRBPGGT1B | |
| SCHEMBL7440851 | 0.78 | GRIK1 (0.34) | GRIK1FNTAFNTBTHRBPGGT1B | |
| SCHEMBL7440860 | 0.78 | GRIK1 (0.34) | GRIK1FNTAFNTBTHRBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241281-B1 | Substituted thiacycloalkeno [3,2-b] pyridines, methods of preparation, compositions and method of use | ORTHO PHARMA CORP (US) | 1994-07-27 | — | — | EP | disclosed |
| US-4879384-A | CYCLIC THIAALKANONE DIOXIDE AND UNSATURATED AMINE ESTER | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-07 | — | — | US | disclosed |
| US-4845225-A | CARDIOVASCULAR, ANTIASTHMATIC AND ANTIBRONCHOCONSTRICTOR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-07-04 | — | — | US | disclosed |
| US-4777167-A | CALCIUM CHANNEL ANTAGONIST, ANTICOAGULANTS, ANTIASTHMATIC, BRONCHODILATOR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-10-11 | — | — | US | disclosed |
| US-4705785-A | Substituted thiacycloalkeno (3,2-b) pyridines and pharmaceutical compositions and method of use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-10 | — | — | US | disclosed |
| EP-0241281-A2 | Substituted thiacycloalkeno [3,2-b] pyridines, methods of preparation, compositions and method of use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |