Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 0.80 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.80 |
| ▸ | GALR3 | O60755 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | PDE4A | P27815 | 3/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31117104 | 0.90 | PDE3B (0.78) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL16156967 | 0.90 | PDE3B (0.78) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL16156959 | 0.89 | PDE3B (1.00) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL992766 | 0.87 | GALR3 (0.72) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL30100309 | 0.84 | GALR3 (0.69) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL21225874 | 0.84 | GALR3 (0.69) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL11097056 | 0.83 | GALR3 (0.64) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL16157197 | 0.83 | GALR3 (0.67) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL31117110 | 0.83 | GALR3 (0.67) | PDE3BPDE3AGALR3MAPTTHRB | |
| SCHEMBL11366466 | 0.83 | GALR3 (0.64) | PDE3BPDE3AGALR3MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327800-B1 | 6-PHENYLDIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | HEUMANN PHARMA GMBH & CO (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4954501-A | INOTROPIC AGENTS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-09-04 | — | — | US | disclosed |