SCHEMBL7267693

SCHEMBL7267693

CC(C)(C)NC(=O)[C@@H]1CCCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.79
ADORA2A P29274 1/20 0.79
ADORA2B P29275 1/20 0.79
ADORA1 P30542 1/20 0.79
CYP3A4 P08684 8/20 0.58
OPRK1 P41145 2/20 0.58
ABCC3 O15438 1/20 0.58
ABCC4 O15439 1/20 0.58
CACNA1F O60840 1/20 0.58
ABCB11 O95342 1/20 0.58
ABCB1 P08183 1/20 0.58
HTR1A P08908 1/20 0.58
DRD2 P14416 1/20 0.58
TACR2 P21452 1/20 0.58
TBXAS1 P24557 1/20 0.58
OPRM1 P35372 1/20 0.58
DRD3 P35462 1/20 0.58
AVPR1A P37288 1/20 0.58
OPRD1 P41143 1/20 0.58
HTR2B P41595 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7267808 0.90 ADORA3 (0.62) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7268072 0.89 CYP3A4 (0.72) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7621294 0.89 CYP3A4 (0.72) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7387484 0.89 ADORA3 (0.69) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7276319 0.89 ADORA3 (0.63) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7388913 0.89 ADORA3 (0.69) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7276414 0.88 ADORA3 (0.81) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7292084 0.88 ADORA3 (0.81) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7276403 0.88 ADORA3 (0.81) ADORA3ADORA2AADORA2BADORA1CYP3A4
SCHEMBL7269347 0.88 ADORA3 (1.00) ADORA3ADORA2AADORA2BADORA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0346847-B1 Amino acid derivatives HOFFMANN LA ROCHE (CH) 1994-05-11 EP claimed
EP-0346847-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1989-12-20 EP claimed
US-6008228-A COMPRISING A MIXTURE OF CARRIER MONOGLYCERIDES OF MEDIUM CHAIN-FATTY ACIDS HOFFMAN-LA ROCHE INC. (US) 1999-12-28 US disclosed
US-5652369-A PROTEASE INHIBITOR HOFFMANN-LA ROCHE INC. (US) 1997-07-29 US disclosed
US-5620987-A Amino acid derivatives HOFFMANN-LA ROCHE INC. (US) 1997-04-15 US disclosed
US-5554756-A PROTEASE INHIBITOR HOFFMANN-LA ROCHE INC. (US) 1996-09-10 US disclosed
US-5446161-A Protease inhibitor, viricides HOFFMANN-LA ROCHE INC. (US) 1995-08-29 US disclosed
EP-0346847-B1 Amino acid derivatives HOFFMANN LA ROCHE (CH) 1994-05-11 EP disclosed
US-5157041-A Viricides HOFFMANN-LA ROCHE INC. (US) 1992-10-20 US disclosed
EP-0346847-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1989-12-20 EP disclosed