Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | QPCT | Q16769 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262631 | 0.87 | GSK3A (0.52) | GSK3AGSK3BQPCTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3976448 | 0.81 | GSK3A (0.76) | GSK3AGSK3BQPCTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7262644 | 0.81 | MEN1 (0.71) | ALDH1A1KDM4EMAPTMAPK1MEN1 | |
| SCHEMBL7262687 | 0.81 | MEN1 (0.65) | SMN1; SMN2ALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL3978895 | 0.81 | GSK3A (0.79) | GSK3AGSK3BQPCTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7267768 | 0.79 | MEN1 (0.60) | ALDH1A1KDM4EMAPTMAPK1MEN1 | |
| SCHEMBL7262660 | 0.79 | HTT (0.68) | ALDH1A1KDM4EMAPTMAPK1MEN1 | |
| SCHEMBL7262661 | 0.78 | PGK1 (0.61) | SMN1; SMN2ALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL7261431 | 0.75 | HTT (0.56) | SMN1; SMN2ALDH1A1KDM4EMAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7266371 | 0.74 | POLB (0.47) | ALDH1A1KDM4EMAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |