Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.60 |
| ▸ | GALR3 | O60755 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276740 | 0.86 | PDE3B (0.64) | PDE3BPDE3AGALR3PDE4APDE4B | |
| SCHEMBL7275287 | 0.84 | PDE3B (0.62) | PDE3BPDE3AGALR3PDE4APDE4B | |
| SCHEMBL7275405 | 0.84 | PDE3B (0.62) | PDE3BPDE3AGALR3PDE4APDE4B | |
| Hydrochloric Acid SCHEMBL7275705 | 0.82 | PDE3B (0.60) | PDE3BPDE3AGALR3PDE4APDE4B | |
| SCHEMBL7266756 | 0.82 | PDE3B (0.71) | PDE3BPDE3AGALR3PDE4APDE4B | |
| SCHEMBL7274472 | 0.82 | PDE3B (0.60) | PDE3BPDE3AGALR3PDE4APDE4B | |
| SCHEMBL7276606 | 0.76 | PDE3B (0.64) | PDE3BPDE3AGALR3ALDH1A1PDE4A | |
| SCHEMBL7273746 | 0.75 | PDE3B (0.56) | PDE3BPDE3AGALR3PDE4APDE4B | |
| SCHEMBL6557142 | 0.75 | PDE3B (1.00) | PDE3BPDE3AGALR3ALDH1A1GPR119 | |
| SCHEMBL7267528 | 0.74 | PDE3B (0.54) | PDE3BPDE3AALDH1A1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326307-B1 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO KK (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5063227-A | QUINAZOLINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES HAVING CARDIOTONIC ACTIVITY | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| EP-0326307-A2 | Novel pyridazinone derivatives and pharmaceutical preparations containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |