Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.44 |
| ▸ | KDM6B | O15054 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5087701 | 0.87 | SIRT1 (0.65) | SIRT1PTGS1PTGS2SLC22A12KDM4E | |
| SCHEMBL21056657 | 0.86 | PTGS1 (0.50) | SIRT1PTGS1PTGS2SLC22A12KDM4C | |
| SCHEMBL30997714 | 0.86 | PTGS1 (0.50) | SIRT1PTGS1PTGS2SLC22A12KDM4C | |
| Nitrous Acid SCHEMBL29269841 | 0.81 | PTGS1 (0.46) | SIRT1PTGS1PTGS2SLC22A12KDM4C | |
| SCHEMBL1656950 | 0.80 | POLB (0.52) | SLC22A12KDM4CKDM4DKDM6BMEN1 | |
| SCHEMBL11504517 | 0.78 | KDM4C (0.50) | SLC22A12KDM4CKDM4DKDM6BMEN1 | |
| SCHEMBL231042 | 0.77 | SIRT1 (0.71) | SIRT1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL30997722 | 0.77 | KDM4C (0.55) | PTGS1PTGS2SLC22A12KDM4CKDM4D | |
| SCHEMBL3074800 | 0.77 | KDM4C (0.49) | SLC22A12KDM4CKDM4DKDM6BMEN1 | |
| SCHEMBL10469069 | 0.76 | CA12 (0.57) | KDM4CKDM4DKDM6BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360489-A1 | LOW AFFINITY SCREENING METHOD | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |