Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15744771 | 0.92 | KDM4E (0.74) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL20887367 | 0.91 | KDM4E (0.72) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL20887271 | 0.87 | KDM4E (0.67) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL1445451 | 0.87 | KDM4E (1.00) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL17437886 | 0.86 | KDM4E (0.78) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL8606874 | 0.85 | KDM4E (0.65) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL15767159 | 0.85 | KDM4E (0.76) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL1647902 | 0.85 | KDM4E (0.76) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL975342 | 0.85 | KDM4E (0.76) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL16691126 | 0.85 | KDM4E (0.76) | KDM4EPOLBGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0370381-A2 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |