Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.50 |
| ▸ | GAA | P10253 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | GLA | P06280 | 5/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20766465 | 0.88 | MAOB (0.66) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL30523691 | 0.88 | MAOB (0.66) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL6591837 | 0.85 | MAPT (0.61) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL9765386 | 0.81 | HTR2A (0.45) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL31513302 | 0.81 | HTR2A (0.45) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL6591390 | 0.81 | MAPT (0.57) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL8797759 | 0.80 | MAOB (0.42) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL9198669 | 0.80 | MAOB (0.44) | MAPTMAOBKDM4EALDH1A1GAA | |
| SCHEMBL8312866 | 0.79 | HTR2A (0.41) | MAPTMAOBMALT1HTR2APGR | |
| SCHEMBL8535332 | 0.79 | HTR2A (0.44) | MAPTMAOBKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | claimed |
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0425980-B1 | Process for the separation of enantiomers of benzopyran derivatives | MERCK PATENT GMBH (DE) | 1994-07-27 | — | — | EP | disclosed |
| EP-0340718-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1994-07-20 | — | — | EP | disclosed |
| EP-0410208-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1994-06-22 | — | — | EP | disclosed |
| US-5103025-A | PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF BENZOPYRAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-07 | — | — | US | disclosed |
| US-5071871-A | Pharmaceutically useful benzo(β)pyranes and pyranopyridines | SANDOZ LTD. (CH) | 1991-12-10 | — | — | US | disclosed |
| EP-0425980-A1 | Process for the separation of enantiomers of benzopyran derivatives | MERCK PATENT GmbH (DE) | 1991-05-08 | — | — | EP | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0410208-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-30 | — | — | EP | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |
| EP-0346724-A1 | Chroman derivates | MERCK PATENT GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |