Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198669 | 0.87 | MAOB (0.44) | HTR2AMAOBMAPTKDM4EKLK7 | |
| SCHEMBL31513302 | 0.86 | HTR2A (0.45) | HTR2AMAOBMAPTKDM4EALDH1A1 | |
| SCHEMBL9765386 | 0.86 | HTR2A (0.45) | HTR2AMAOBMAPTKDM4EALDH1A1 | |
| SCHEMBL8131499 | 0.84 | HTR2A (0.47) | HTR2AMAOBMAPTKDM4EKLK7 | |
| SCHEMBL23084661 | 0.82 | HTR2A (0.42) | HTR2AMAOBMAPTKDM4EALDH1A1 | |
| SCHEMBL8539965 | 0.81 | MAPT (0.43) | HTR2AMAOBMAPTKDM4EKLK7 | |
| SCHEMBL8541285 | 0.81 | KDM4E (0.42) | HTR2AMAOBMAPTKDM4EKLK7 | |
| SCHEMBL7269382 | 0.79 | MAPT (0.61) | HTR2AMAOBMAPTKDM4EALDH1A1 | |
| SCHEMBL8539954 | 0.77 | NPC1 (0.44) | MAPTKDM4EKLK7ALDH1A1GAA | |
| SCHEMBL8797759 | 0.77 | MAOB (0.42) | HTR2AMAOBMAPTKDM4EKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719155-A | CARDIOVASCULAR DISORDERS | JAPAN TOBACCO INC. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0677519-A1 | CHROMAN DERIVATIVE AND MEDICINAL USE THEREOF | Japan Tobacco Inc. (JP) | 1995-10-18 | — | — | EP | disclosed |