Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.59 |
| ▸ | PDE5A | O76074 | 8/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269747 | 0.97 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7269993 | 0.96 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7027210 | 0.95 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7624361 | 0.82 | ADORA1 (0.43) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7269780 | 0.80 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7620828 | 0.80 | ADORA1 (0.45) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7624371 | 0.80 | ADORA2B (0.43) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7618352 | 0.79 | ADORA2A (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7270168 | 0.77 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7620841 | 0.77 | ADORA2B (0.45) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120417-A2 | Xanthine derivatives for the treatment of cerebrovascular disorders | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 2001-08-01 | — | — | EP | claimed |
| US-5981535-A | FOR TREATMENT OF ALLERGIC DISORDERS ASSOCIATED WITH ATOPY, BRONCHODILATION TO TREAT DISORDERS OF THE RESPIRATORY TRACT IN A MAMMAL | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-09 | — | — | US | claimed |
| US-5734051-A | TREATMENT OF CEREBROVASCULAR DISORDERS AND-OR DISORDERS ASSOCIATED WITH CEREBRAL SENILITY | BEECHAM GROUP (GB) | 1998-03-31 | — | — | US | claimed |
| EP-0558659-A4 | TNF INHIBITORS | — | 1993-10-20 | — | — | EP | claimed |
| EP-0558659-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-08 | — | — | EP | claimed |
| WO-1993016699-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | claimed |
| WO-1992009203-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-11 | — | — | WO | claimed |
| EP-0389282-A2 | Xanthinederivatives, process for their preparation and their pharmaceutical use | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1990-09-26 | — | — | EP | claimed |
| EP-0558659-A4 | TNF INHIBITORS | — | 1993-10-20 | — | — | EP | disclosed |
| EP-0558659-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-08 | — | — | EP | disclosed |
| WO-1993016699-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |
| WO-1992009203-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |