Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CFB | P00751 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057010 | 0.94 | SPHK2 (0.56) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| SCHEMBL11983314 | 0.94 | SPHK2 (0.56) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| SCHEMBL7792025 | 0.94 | SPHK2 (0.56) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| SCHEMBL23777202 | 0.89 | SPHK2 (0.56) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| SCHEMBL7367083 | 0.89 | SPHK2 (0.56) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| SCHEMBL10867079 | 0.87 | SPHK2 (0.45) | SPHK2SPHK1S1PR1S1PR3S1PR5 | |
| SCHEMBL23866033 | 0.87 | SPHK2 (0.58) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| SCHEMBL7270850 | 0.87 | SPHK2 (0.58) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL27684543 | 0.87 | SPHK2 (0.55) | SPHK2SPHK1GBA1S1PR1S1PR3 | |
| SCHEMBL23865736 | 0.87 | SPHK2 (0.58) | SPHK2SPHK1GBA1S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012175962-A1 | COMPOUNDS FOR USE IN STABILISING p53 MUTANTS | MEDICAL RESEARCH COUNCIL (GB) | 2012-12-27 | — | — | WO | disclosed |
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
| US-20100048565-A1 | BENZIMIDAZOLE DERIVATIVES | FRENKEL ALEXANDER DAVID | 2010-02-25 | — | — | US | disclosed |
| US-7635774-B2 | 2-Amino-imidazole derivatives; modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation | AMGEN INC. (US) | 2009-12-22 | — | — | US | disclosed |
| EP-1558567-B1 | NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-06-24 | — | — | EP | disclosed |
| US-20070037803-A1 | 2-Amino-imidazole derivatives; modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation | AMGEN SF, LLC (US) | 2007-02-15 | — | — | US | disclosed |
| EP-0429984-B1 | Indole derivatives | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5124324-A | Psychological disorders, 5-hydroxy tryptamine antagonists | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-06-23 | — | — | US | disclosed |
| EP-0429984-A2 | Indole derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037803-A1 | 2-Amino-imidazole derivatives; modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation | IDO2, IRF2BP2, IRF3 | SPHK2 2126/4885SPHK1 3091/4885GBA1 4868/4885 |
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | SPHK2 676/4885SPHK1 563/4885GBA1 1093/4885 |
| US-20100048565-A1 | BENZIMIDAZOLE DERIVATIVES | NFATC1, STAT1, IRF3 | SPHK2 2416/4885SPHK1 3098/4885GBA1 4037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.