Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939837 | 1.00 | MEN1 (0.44) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL7271653 | 0.85 | MEN1 (0.55) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL6936026 | 0.85 | MEN1 (0.55) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL2832770 | 0.85 | LRRK2 (0.47) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL2832767 | 0.85 | LRRK2 (0.47) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL2832810 | 0.84 | CA12 (0.48) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL2832813 | 0.84 | CA12 (0.48) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL2834447 | 0.84 | CA12 (0.48) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL2834451 | 0.84 | CA12 (0.48) | MEN1KMT2ATGM2CES1LRRK2 | |
| SCHEMBL4895008 | 0.84 | KMT2A (0.52) | MEN1KMT2ALRRK2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030229453-A1 | Crystals and structures of PAK4KD kinase PAK4KD | SGX PHARMACEUTICALS, INC. | 2003-12-11 | — | — | US | disclosed |